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Cross-sectional study · protocol stage · Sep 2026

Autistic traits and academic performance in medical students

In general college populations, higher autistic trait scores predict lower grades. Medical students are selected for academic achievement — does the same relationship hold in a group chosen for exactly the outcome being measured?

Read the protocol ↗

The gap

Autistic traits sit on a continuum across the whole population, diagnosis or not. The Autism-Spectrum Quotient measures them, and its items cluster into two largely independent dimensions: Social Interaction, and Attention to Detail.

Medicine complicates the picture. Medical students score lower on the AQ than other STEM students, yet within medicine, higher scores predict a preference for technique-focused specialties. Some of these traits — deep focus, attention to detail, less reliance on interpersonal nuance — are quietly rewarded in medical training.

No cross-sectional study has yet tested dimensionally measured autistic traits against academic performance within a medical student population, and almost none of the existing work looks outside North America and Europe. This study addresses both gaps from Egypt.

Aims

Primary
Does the Total AQ-50 score correlate with GPA among medical students? Hypothesised negative, consistent with general college populations.
Secondary — exploratory
Do the Social Interaction and Attention to Detail factor scores relate to GPA differently? The two dimensions may pull in opposite directions in this setting.
Secondary — psychometric
Report internal consistency (Cronbach's alpha, item-rest correlations) for the Arabic AQ-50 in this sample — evidence that does not yet exist in the literature.

Instrument note

The study uses the full 50-item AQ in the official Arabic translation from the Cambridge Autism Research Centre — not the shorter AQ-28, which has been validated in Arabic but is a distinct instrument with different items and a different factor structure. Validation of one does not transfer to the other.

The Cambridge translation confirms the Arabic wording of the items; it says nothing about whether the two-factor structure holds in an Arabic-speaking sample. Because that evidence doesn't exist yet, the factor-score findings are treated as exploratory and reported alongside this study's own reliability estimates.

Team

Motaz Mazen Al-Qawasma Principal investigator · Alexandria University · ORCID 0009-0002-0232-3789
Mohammad Kamel Assi Co-investigator · Alexandria University · ORCID 0009-0008-7087-3292